Natural Sciences Building # 8315
+82-2-6490-2673
jchoe@uos.ac.kr
My research area is structural biology using X-ray crystallography. After studying chemistry in undergraduate school, I joined Dr. Sewon Suh’s group to study crystallography. During the Ph. D. program in Dr. Wim Hol’s lab in University of Washington, Seattle, I worked on the structure-based drug design project targeting the glycolytic enzymes from the parasite, Trypanosoma brucei. In Dr. Ian Wilson’s group as a postdoc, my research interest was proteins involved in the human innate immune system including Toll-like receptors. I determined the crystal structure of TLR3, which recognizes the double-stranded RNA from virus.
Professor Choe’s current research interests include
1. Adaptor proteins involved in the signaling process of Toll-like receptors such as MyD88, TIRAP, TRAM and Trif
2. Innate immune receptors including TLR, RLR and NLR
3. Bacterial proteins involved in diverse metabolic processes
Education
Ph.D. Department of biochemistry, University of Washington (X-ray crystallography)
M.S. Department of chemistry, Seoul National University (X-ray crystallography)
B.S, Department of chemistry, Seoul National University
Academic Appointments
2012 - present, Associate Professor of Life Sciences, College of Natural Science, University of Seoul
2007 - 2012, Assistant Professor of Life Sciences, College of Natural Science, University of Seoul
2003 – 2007, Researcher, The Scripps Research Institute, San Diego, USA
PUBLICATIONS
Baek SE, Kim H, Kim KB, Yoon S, Choe J, Suh W, Jeong YJ, Cho YH, Kim DE. Dual effects of duplex RNA harboring 5'-terminal triphosphate on gene silencing and RIG-I mediated innate immune response. Biochem Biophys Res Commun. 2015 Jan 9;456(2): 591-7. doi: 10.1016/j.bbrc.2014.11.119. Epub 2014 Dec 6. PubMed PMID: 25490387.
Kim Y, Lee H, Heo L, Seok C, Choe J. Structure of vaccinia virus A46, an inhibitor of TLR4 signaling pathway, shows the conformation of VIPER motif. Protein Sci. 2014 Jul;23(7):906-14. doi: 10.1002/pro.2472. Epub 2014 Apr 28. PubMed PMID: 24723367; PubMed Central PMCID: PMC4088974.
Park S, Kim D, Jang I, Oh HB, Choe J. Structural and biochemical study of Bacillus subtilis HmoB in complex with heme. Biochem Biophys Res Commun. 2014 Mar 28;446(1):286-91. doi: 10.1016/j.bbrc.2014.02.092. Epub 2014 Feb 28. PubMed PMID:
24582752.
Kim Y, Kang Y, Choe J. Crystal structure of Pseudomonas aeruginosa transcriptional regulator PA2196 bound to its operator DNA. Biochem Biophys Res Commun. 2013 Oct 18;440(2):317-21. doi: 10.1016/j.bbrc.2013.09.074. Epub 2013 Sep 23. PubMed PMID: 24070609.
Kim H, Choe J. The X-ray crystal structure of PA1374 from Pseudomonas aeruginosa, a putative oxidative-stress sensing transcriptional regulator. Biochem Biophys Res Commun. 2013 Feb 15;431(3):376-81. doi: 10.1016/j.bbrc.2013.01.044. Epub 2013 Jan 18. PubMed PMID: 23337505.
Park S, Choi S, Choe J. Bacillus subtilis HmoB is a heme oxygenase with a novel structure. BMB Rep. 2012 Apr;45(4):239-41. PubMed PMID: 22531134.
Kang Y, Choe J. Crystal structure of Pseudomonas aeruginosa PA2196, a putative TetR family transcriptional repressor. Biochem Biophys Res Commun. 2011 Jun 24;410(1):52-6. doi: 10.1016/j.bbrc.2011.05.103. Epub 2011 May 24. PubMed PMID: 21635871.
Choi S, Choe J. Crystal structure of elongation factor P from Pseudomonas aeruginosa at 1.75 Å resolution. Proteins. 2011 May;79(5):1688-93. doi: 10.1002/prot.22992. Epub 2011 Mar 1. PubMed PMID: 21365687.
Moon H, Han S, Park H, Choe J. Crystal structures of human FIH-1 in complex with quinol family inhibitors. Mol Cells. 2010 May;29(5):471-4. doi: 10.1007/s10059-010-0058-3. Epub 2010 Apr 12. Erratum in: Mol Cells. 2010 Jun;29(6):625. PubMed PMID: 20396966.
Moon H, Choe J. Crystallization and preliminary crystallographic studies of human RIG-I in complex with double-stranded RNA. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jun 1;65(Pt 6):648-50. doi: 10.1107/S1744309109018405. Epub 2009 May 23. PubMed PMID: 19478455; PubMed Central PMCID: PMC2688434.
Jiang Z, Georgel P, Li C, Choe J, Crozat K, Rutschmann S, Du X, Bigby T, Mudd S, Sovath S, Wilson IA, Olson A, Beutler B. Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis. Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10961-6. Epub 2006 Jul 10. PubMed PMID: 16832055; PubMed Central PMCID: PMC1544157.
Choe J, Kelker MS, Wilson IA. Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science. 2005 Jul 22;309 (5734): 581-5. Epub 2005 Jun 16. PubMed PMID: 15961631.
Moyersoen J, Choe J, Fan E, Hol WG, Michels PA. Biogenesis of peroxisomes and glycosomes: trypanosomatid glycosome assembly is a promising new drug target. FEMS Microbiol Rev. 2004 Nov;28(5):603-43. Review. PubMed PMID: 15539076.
Choe J, Moyersoen J, Roach C, Carter TL, Fan E, Michels PA, Hol WG. Analysis of the sequence motifs responsible for the interactions of peroxins 14 and 5, which are involved in glycosome biogenesis in Trypanosoma brucei. Biochemistry. 2003 Sep 23;42(37):10915-22. PubMed PMID: 12974625.
Choe J, Guerra D, Michels PA, Hol WG. Leishmania mexicana glycerol-3-phosphate dehydrogenase showed conformational changes upon binding a bi-substrate adduct. J Mol Biol. 2003 May 30;329(2):335-49. PubMed PMID: 12758080.
Moyersoen J, Choe J, Kumar A, Voncken FG, Hol WG, Michels PA. Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins. Eur J Biochem. 2003 May;270(9):2059-67. PubMed PMID: 12709066.
Choe J, Suresh S, Wisedchaisri G, Kennedy KJ, Gelb MH, Hol WG. Anomalousdifferences of light elements in determining precise binding modes of ligands to glycerol-3-phosphate dehydrogenase. Chem Biol. 2002 Nov;9(11):1189-97. PubMed
PMID: 12445769.
Awards, Fellowship and Honors
Ruth L. Kirschstein National Research Service Award
The Skaggs Institute post-doctoral fellowship
Academic Courses Taught
Biochemistry I, II
Bioinformatics
Experimental biochemistry and biotechnology
Professional Membership
Member of Korean Crystallographic association
Member of Korean Chemical Society
