HWANG, EUN-SEONG
Professor
Natural Science Building # 8508
+82-2-6490-2669
eshwang@uos.ac.kr
Eun Seong Hwang is a professor of Department of Life Science at the University of Seoul. Before joining UOS in 1997, professor Hwang worked at Yale University as a research associate studying the role of human papillomavirus in cervical cancer. After he came back to Korea at 1994, he worked at Samsung Biomedical Research institute as a senior researcher developing gene therapy protocols for human cancers. Although he still has interest in thesee fields of life science, he is currently working on cell biology of aging. At 2000, he started to publish papers on cellular senescence, and since then, his lab is heavily focused on this subject as well as the role of mitochondria in aging at cellular level. His research puts great emphasis on fundamental cell biology trying to understand the basic phenomena related to aging. “Senescence-associated β-galactosidase is lysosomal β-galactosidase” which has been cited 270 times by 2014, is one typical product of such research effort. His lab, the lab of Tumor virology and Cellular Senescence, has raised near 20 masters and Ph.Ds. by 2013. The lab has been maintaining couple ofl master course students and similar number of Ph.D students for years, and now is leading the nation for leading edge research on cellular senescence and mitochondria biology.
Professor Hwang is also active academcally and socially. He has worked as Dean of Research Affairs and the President of UOS Industry Cooperation Foundation of the University of Seoul. He established systems to promote research ethics and morale of graduate students. He also served as president of the Korean society for gerontology and promoted aging research in the nation. He also is actively engaged in education of research ethics by giving lectures and counselings to students and editors of domestic as well as foreign journals.
Professor Hwang is also active academcally and socially. He has worked as Dean of Research Affairs and the President of UOS Industry Cooperation Foundation of the University of Seoul. He established systems to promote research ethics and morale of graduate students. He also served as president of the Korean society for gerontology and promoted aging research in the nation. He also is actively engaged in education of research ethics by giving lectures and counselings to students and editors of domestic as well as foreign journals.
Education
Ph.D., Department of Biochemistry, Johns Hopkins University School of Public Health (Biochemistry)
M.A., Department of Food Science, Seoul National University (Food Science)
B.A., Department of Food Science, Seoul National University (Food Sciences)
Academic Appointments
2006 - present, Professor, Department of Life Science, College of Natural Sciences, University of Seoul
2001 - 2006, Associate Professor, Department of Life Science, College of Natural Sciences, University of Seoul
1997 - 2001, Assistant Professor, Department of Life Science, College of Natural Sciences, University of Seoul
1994 - 1997, Senior Scientist, Samsung Biomedical Research Institute
1991 - 1994, Postdoctoral Associate, Department of Genetics, School of Medicine, Yale University
Professional Appointments
2013 – 2015 Dean, Office of Research Affairs, University of Seoul
2013 – 2015 President, University of Seoul Industry Cooperation Foundation
2013 – present Vice President, Federation of Korean Societies for Gerontological Sciences
2013 – present Chairperson, Committee for Publication Ethics, Korean Council of Science Editors
2013 – present Vice Chairperson, Committee for Publication Ethics, Asian Council of Science Editors
2013 – present Aging Cell, Supervising Editor
2013 – 2014 President, Korean Society for Gerontology
2013 – present Aging Cell, Supervising Editor
Awards, Fellowships and Honors
Korean studies abroad Grant, 1984
Brown-Coxe Felloewship, Yale Grant, 1992
Major Research Area
Cellular senescence and aging
Mitochondria physiology
Tumor virology
Ph.D., Department of Biochemistry, Johns Hopkins University School of Public Health (Biochemistry)
M.A., Department of Food Science, Seoul National University (Food Science)
B.A., Department of Food Science, Seoul National University (Food Sciences)
Academic Appointments
2006 - present, Professor, Department of Life Science, College of Natural Sciences, University of Seoul
2001 - 2006, Associate Professor, Department of Life Science, College of Natural Sciences, University of Seoul
1997 - 2001, Assistant Professor, Department of Life Science, College of Natural Sciences, University of Seoul
1994 - 1997, Senior Scientist, Samsung Biomedical Research Institute
1991 - 1994, Postdoctoral Associate, Department of Genetics, School of Medicine, Yale University
Professional Appointments
2013 – 2015 Dean, Office of Research Affairs, University of Seoul
2013 – 2015 President, University of Seoul Industry Cooperation Foundation
2013 – present Vice President, Federation of Korean Societies for Gerontological Sciences
2013 – present Chairperson, Committee for Publication Ethics, Korean Council of Science Editors
2013 – present Vice Chairperson, Committee for Publication Ethics, Asian Council of Science Editors
2013 – present Aging Cell, Supervising Editor
2013 – 2014 President, Korean Society for Gerontology
2013 – present Aging Cell, Supervising Editor
Awards, Fellowships and Honors
Korean studies abroad Grant, 1984
Brown-Coxe Felloewship, Yale Grant, 1992
Major Research Area
Cellular senescence and aging
Mitochondria physiology
Tumor virology
Papers
(1) Characteristics of two yeast strains and conditions for the protoplast formation and regeneration as a preliminary step in interspecific protoplast-fusion. 1984. Seoul Nat'l University, College of Agriculture Research 9: 1-16. K.H. Lee, K.H. Park, H.J. Lee, E.S. Hwang, H.C. Suh, B.H. Oh, and H.D. Jang
(2) Epstein-Barr Virus Nuclear Antigen Forms a Complex That Binds with High Concentration Dependence to a Single DNA-binding Site. 1987. J. Virology 61: 465-471. Gregory Milman and Eun Seong Hwang.
(3) Interaction of Integration Host Factor from Escherichia coli with the Integration Region of the Haemophilus influenzae Bacteriophage HP1. 1990. J. Bacteriology 172: 4852-4860. Eun Seong Hwang and John J. Scocca.
(4) Targeted Cleavage of Messenger RNA by Human RNaseP. 1992. Proceedings of the National Academy of Science, U.S.A. 89: 8001-8005. Yan Yuan, Eun Seong Hwang, and Sidney Altman.
(5) A method of cloning multiple direct repeats of DNA segment. 1993. Biotechniques 14: 766-767. Eun Seong Hwang and John J. Scocca.
(6) Inhibition of Cervical Carcinoma Cell Line Proliferation by Introduction of a Bovine Papillomavirus Regulatory Gene. 1993. J. Virology 67: 3720-3729. Eun Seong Hwang, David J. Riese,II, Jeffrey Settleman, Laura Nilson, Julie Honig, Stuart Flynn, and Daniel DiMaio.
(7) The E5 transforming Proteins of The Papillomaviruses. 1994. Seminars in Virology 5: 369-379. Daniel DiMaio, Lisa Petti, and Eun Seong Hwang.
(8) The HPV16 E5 Protein: Expression, Detection, and Stable Complex Formation with Trans-membrane Proteins in Cos Cells. 1995. Virology 211: 227-233. Eun Seong Hwang, Timothy Nottoli, and Daniel DiMaio.
(9) Endogenous Gene Expression of p53 and Regulatory Subunits of Cyclic AMP-dependent Protein Kinase in Ovarian Cancer Cells. 1995. Korean J. Zool. 38: 204-211. Jin Seo, Woonmee Park, Jong Sik Kim, Eun Seong Hwang, Je-Ho Lee, and Seung Hwan Hong.
(10) Activation of Endogenous Growth Inhibitory Pathways in HeLa Cervical Carcinoma Cells by Expression of the Bovine Papillomavirus E2 Gene. 1996. Oncogene 12:795-803. Eun Seong Hwang, Lisa K. Naeger, and Daniel DiMaio.
(12) Seroreactivities to HPV-16 Virus Like Particles (VLPs) using ELISA in the Patients with Cervical Neoplasia. 1996. Korean J Gynecology 39: 176-185. Jong Sup Park, Eun Seong Hwang, Hee Kyoung Ahn, Chan Ju Kim, Keun Taik Chung, Hyun Su Kim, Sue Nie Park, Sung Eun Namkoong, Seung Jo Kim.
(13) Identification of a Variant Estrogen Receptor Lacking Exon4 and Its Coexpression with Wild-type Estrogen Receptor in Ovarian Carcinomas. 1996. Clinical Cancer Research 2:2029- 2035. Weonmee Park, Jung-Joo Choi, Eun Seong Hwang, Je-Ho Lee.
(14) Physical Status and Expression of HPV Genes in Cervical Cancers. 1997. Gynecologic Oncol. 65: 121-129. Jong Sup Park, Eun Seong Hwang, Sue Nie Park, Hee Kyoung Ahn, Hye Kyung Yang, Chan Ju Kim, Seung Jo Kim, Sung Eun Namkoong.
(15) TypeII Protein Kinase A Up-regulation is Sufficient to Induce Growth Inhibition in SK-N-SH Human Neuroblastoma Cells. 1997. Biochem. Biophy. Res. Com. 232: 469-473. Se Nyun Kim, Gap Ryol Lee, Eun Seong Hwang, Je-HoLee, Sang Dai Park, Yoon S. Cho-Chung, and Seung Hwan Hong.
(16) Limited cytotoxic effect of adenoviral-mediated p53 gene transfer in variable non-small cell lung cancer (NSCLC) cell lines. J Korean Cancer Assoc. 1997. 29(45):565-57. Kim J, Lee SH, Hwang ES, Kim JS, Kim K, Lee JH.
(17) The effects of the adenovirus-mediated wild-type p53 delivery in human ovarian cancer cell lines in vitro and in vivo. 1998. International J. of Gynecol Cancer 8:27-36. Eun Seong Hwang, Jhingook Kim, Jong Sik Kim, Chinghai Kao, Song-Chu Ko, Lelend Chung, and Je-Ho Lee.
(18) Immunresponse to p53 and HPV16 E6 proteins in patients with cervical vacncer. 1998. International J. of Gynecol Cancer 8:542-547. Jong Sup Park, Soo Jong Um, Eun Seong Hwang, Sue Nie Park, Hee Kyoung Ahn, Chan Ju Kim, Sung Eun Namkoong.
(19) Induction of senescence-like state in HeLa cells by the expression of bovine papillomavirus E2 gene. 1998. Korean J Gerontology 8:57-65. Eun Seong Hwang
(20) Intraperitoneal gene therapy with adenoviral-mediated p53 tumor suppressor gene for ovarian cancer model in nude mouse. 1999. Cancer gene therapy. 6:172-178. Jhingook Kim, Eun Seong Hwang, Jong Sik Kim, Eun Hoi Ryu, Sook Hyun Lee, Je-Ho Lee.
(21) The antibody response to HPV proteins and genomic state of HPVs in patients with cervical cancer. 1999. Intern. J. of Gynecol Cancer 9:1-11. CJ Kim, SJ Um, ES Hwang, SN Park, SJ Kim, SE Namkoong.
(22) Bovine papillomavirus E2 protein activates a complex growth-inhibitory program in p53-negative HT-3 cervical carcinoma cells that includes repression of cyclin A and cdc25A phosphatase genes and accumulation of hypophosphorylated retinoblastoma protein. 1999. Cell Growth and Differentiation 10:1-10. L Naeger, E Goodwin, ES Hwang, R DeFillipis, H Zhang, and D DiMaio.
(23) Mutational and functional analysis of HPV16 URR derived from Korean cervical neoplasia. 1999. Gynecol Oncology 74:23-29. JS Park, ES Hwang, CJ Lee, CJ Kim, JG Rha, ES Namkoong, SJ Um.
(24) Antiproliferative effects of retinoic acid/interferon in cervical carcinoma cell lines: cooperative growth suppression of IRF-1 and p53. 2000. International J Cancer. 85:416-423. SJ Um, EJ Kim, ES Hwang, SJ Kim, SE Namkoong, JS Park.
(25) Inactivation of Interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. 2000. J Biol Chem. 275:6764-6769. JS Park, EJ Kim, HJ Kwon, ES Hwang, SE Namkoong, SJ Um
(26) Cellular machineries that regulate p53 tumor suppressor activity. 1999. Biochemistry News 19: 194-201. Eun Seong Hwang
(27) Rapid Induction of senescence in human cervical carcinoma cells. 2000. Proceedings of the National Academy of Science, U.S.A. 97:10978-10983. EC Goodwin, E Yang, CJ Lee, HW Lee, D DiMaio, ES Hwang
(28) Endothelin-1 autocrine is suppressed in HeLa cells induced to a senescent state. 2000. Korean J. Gerontology 10:31-37. Chan-Jae Lee, Jae-Yong Lee, Young-Sook Song and Eun Seong Hwang
(29) Effect of BPV1 E2-mediated inhibition of E6/E7 expression in HPV16-positive cervical carcinoma cells. 2001. Gynecol Oncology 80:168-175. MS Moon, CJ Lee, SJ Um, JS Park, JM Yang, ES Hwang
(29) Endothelin-1 autocrine is suppressed in HeLa cells induced to a senescent state. 2000. Korean J. Gerontology 10:31-37. Chan-Jae Lee, Jae-Yong Lee, Young-Sook Song and Eun Seong Hwang
(31) Abrogation of IRF-1 response by high-risk HPV E7 protein in vivo. 2002. Cancer Letters. 179: 205-212. Soo-Jong Um, Jae-Woong Rhyu, Eun-Joo Kim, Kook-Che Jeon, Eun Seong Hwang, Jong-Sup Park.
(32) Induction of Senescence-like State and Suppression of Telomerase Activity Through Inhibition of HPV E6/E7 Gene Expression in Cells Immortalized by HPV16 DNA. 2002. Experimental Cell Research. 277:173-82. Chan Jae Lee, Eun Jung Suh, Hyun Tae Kang, Jun Sub Im, Soo Jong Um, Jong Sup Park, and Eun Seong Hwang.
(33) Ribozyme-mediated replacement of p53 RNA by targeted trans-splicing. 2002. Journal of Microbiology and Biotechnology 12: 844-848. Shin, K.-S., Bae, S.-J., Hwang, E.S., Jeong, S., and Lee, S.-W.
(34) Replicative senescence and senescence-like state induced in cancer-derived cells. 2002. Mech Ageing Dev. 123:1681-1694. ES Hwang.
(35) Induction of senescence phenotypes in cancer cells by an acute growth arrest followed by ROS stress. 2002. Korean J Gerontology. 12:31-39. Bo Yun Lee and Eun Seong Hwang.
(36) BRCA1 associates with human papillomavirus type18 E2 and stimulates E2-dependent transcription. 2003. Biochem Biophys Res Comm. 305:1008-1016. Jiyun Kim, Daeyoup Lee, Sun Gwan Hwang, Eun Seong Hwang, Joonho Choe.
(37) 2-Deoxyglucose, a low glucose mimetic, downregulates HPV E6/E7 genes through modulation of glycosylation level of transcription factos in cervical cancer cells. 2003. Korea J. Gerontology. 13: 39-45. Hyun Tae Kang and Eun Seong Hwang.
(38) Downregulation of Sp1 activity through modulation of O-glycosylation by treatment with a low glucose mimetic, 2-deoxyglucose. 2003. J Biol Chem. 278:51223-51231. Hyun Tae Kang, Jung Won Ju, Jin Won Cho, and Eun Seong Hwang
(39) Transition to an irreversible state of senescence in HeLa cells arrested by repression of HPV E6 and E7 genes. 2004. Mech Ageing Dev. 125: 31-40. Hyun Tae Kang, Chan Jae Lee, Eun Jeong Seo, Young Jae Bahn, Hyun Jung Kim, and Eun Seong Hwang
(40) Mechanism of aging and modulation of aging at cellular level. 2004. Journal of Korean Society of Endocrinology. 19: 90-93. Eun Seong Hwang.
(41) The role of HPV oncoproteins and cellular factors in maintenance of hTERT expression in cervical carcinoma cells. 2004. Gynecologic Oncology. 94:40-47. Eun Jeong Seo, Hyun Jung Kim, Chan Jae Lee, Hyun Tae Kang, Eun Seong Hwang.
(42) Dinstinct ROS and biochemical profiles in cells undergoing DNA damage-induced senescence and apoptosis. 2004. Mech Ageing Dev. 126: 580-590. Young Sook Song, Bo Yun Lee, and Eun Seong Hwang
(43) 2-Deoxyglucose: an anti-cancer and anti-viral therapeutic, but not any more a low-glucose mimetic. 2006. Life Sciences 78: 1392-1399. Hyun Tae Kang and Eun Seong Hwang
(44) Senescence-associated β-galactosidase is lysosomal β-galactosidase. 2006. Aging Cell 5: 187-195. Bo Yun Lee, Jung A. Han, Jun Sub Im, Amelia Morrone, Kimberly Johung, Edward C. Goodwin, Wim J Kleijer, Daniel DiMaio, Eun Seong Hwang
(45) DNA-damage is critical to induce cellular senescence but not apoptosis. 2006. Kor J Gerontology. 16: 171-177. Young Sook Song and Eun Seong Hwang
(46) Nicotinamide extends replicative lifespan of human cells. 2006. Aging Cell 5:423-436.
Hyun Tae Kang, Hyung Il Lee, Eun Seong Hwang
(47) Downregulation of transcription factor, Sp1, during cellular senescence. 2007. BBRC. 353: 86-91. Ji-Eun Oh, Jung-A Han, Eun Seong Hwang
(48) DNA-damage is critical to induce cellular senescence but not apoptosis. 2006. Kor J Gerontol 16:171-177. Young Sook Song, Eun Seong Hwang
(49) Heterogeneous upregulation of lysosomal genes in human fibroblasts and cancer cells undergoing senescence. 2007. Korean J. Genetics 29: 521-527. Ji Hoon Park, Hye Won Yi, Daniel DiMaio, Eun Seong Hwang
(50) p53-, SIRT1-, and PARP-1-independent downregulation of p21WAF1 expression in nicotinamide treated Cells.2008. BBRC. 368: 298-304. Hyung I Lee, So-Young Jang, Hyun T Kang, Eun Seong Hwang
(51) Transient downregulation of protein O-GlcNAcylation by high-dose nicotinamide treatment in human cells. 2008. April. Experimental Molecular Medicine. 40: 246-253. Hyung Il Lee, Hwa Jeong Cho, Jung A Han, So-Young Jang, Kyoung Min Wang, Hyun Tae Kang, and Eun Seong Hwang
(52) Comparsion of cellular senescence phenotype in human fibroblasts from new-born and aged donors. 2008. J. Life Science 18:1-6. Hae Won Yi, Eun Seong Hwang
(53) Japan–Korea Joint Seminar: Asian Aging Core for Longevity 2008 in Nagasaki – Toward the establishment of an Asian Aging Research and Education Center. Mech. Ageing Dev. 130: 198–201. Isao Shimokawa, Sang Chul Park, Nozomu Mori, Eun Seong Hwang
(54) Nicotinamide enhances mitochondria quality through autophagy activation in human cells. 2009. Aging Cell. 8: 426–438. Hyun Tae Kang and Eun Seong Hwang
(55) A comparative analysis of the cell biology of senescence and aging. 2009. Cellular and Molecular Life Sciences. 66: 2503-2525. Eun Seong Hwang, Hyun Tae Kang, Gyesoon Yoon
(56) Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: Implication in the retinoic acid-induced neuronal differentiation of P19 cells. 2010. Nucleic Acids Res. 38: 822-831.
Kang MR, Lee SW, Um E, Kang HT, Hwang ES, Kim EJ, Um SJ.
(57) Fluorescence-Based Detection and Quantification of Features of Cellular Senescence. In: Zbigniew Darzynkiewicz, Elena Holden, Alberto Orfao, William Telf and Donald Wlodkowicord, editors: Recent Advances in Cytometry, Part B, Vol 103, Oxford: Academic Press; 2011, p149-188. Eun Seong Hwang
(58) Status of mTOR activity may phenotypically differentiate senescence and quiescence.
MolCells. 2012 Jun;33(6):597-604. Sohee Cho, Eun Seong Hwang
(59) Nicotinamide-induced mitophagy: Event mediated by high NAD+/NADH ratio and SIRT1 protein activation. J Biol Chem. 2012. 287:19304-14. So-young Jang, Hyun Tae Kang, Eun Seong Hwang
(60) GSK3 inactivation is involved in mitochondrial complex IV defect in transforming growth factor (TGF) β1-induced senescence. Exp Cell Res. 2013. 318(15): 1808-19. Byun HO, Jung HJ, Seo YH, Lee YK, Hwang SC, Hwang ES, Yoon G.
(61) Senescence suppressors: their practical importance in replicative lifespan extension in stem cells. Cell. Mol. Life Sci. 2014.71:4207-4219. Eun Seong Hwang
(62) High-Dose Nicotinamide Suppresses ROS Generation and Augments Population Expansion during CD8+ T Cell Activation. Mol. Cells. 2015. 38(10): 918-924. Ho Jin Choi, So-Young Jang, and Eun Seong Hwang
(63) Nicotinamide Exerts Antioxidative Effects on Senescent Cells. Mol Cells. 2015. 31; 38(3): 229–235. Ju Yeon Kwak, Hyun Joo Ham, Cheol Min Kim, and Eun Seong Hwang
(64) Chemical and Physical Approaches to Extend the Replicative and Differentiation Potential of Stem Cells. Stem Cell Rev. 2016. 12(3):315-26. Eun Seong Hwang, Jeong Soo Ok, Seon Beom Song
(65) Increased citation of Korean scholarly journals during the years 2008 to 2013. Sci Ed. 2016. 3(1):13-18. Eun Seong Hwang
(66) Equality, equity, and reality of open access on scholarly information. Sci Ed. 2017. 4(2):58-69. Jeong-Wook Seo, Hosik Chung, Tae-Sul Seo, Youngim Jung, Eun Seong Hwang, Cheol-Heui Yun, Hyungsun Kim
(67) On difficulty in handling text recycling. Sci Ed. 2017. 4(2):86-88. Eun Seong Hwang
(68) Increased number of papers co-authored by professor and his students in humanities and social sciences journals published in Korea. Sci Ed. 2017. 4(1):12-17. Rae Seong Hong, Eun Seong Hwang
(69) Modulation of Mitochondrial Membrane Potential and ROS Generation by Nicotinamide in a Manner Independent of SIRT1 and Mitophagy. Mol. Cells. 2017. 40(7): 503-514. Seon Beom Song, So-Young Jang, Hyun Tae Kang, Bie Wei, Un-woo Jeoun, Gye Soon Yoon, and Eun Seong Hwang
(70) Cellular NAD+ Level: A Key Determinant of Mitochondrial Quality and Health. Annals of Geriatric Medicine and Research. 2017. 21(4):149-157. Eun Seong Hwang, Sung Yun Hwang
(71) Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells. Cell. Mol. Life Sci. 2017. 74(18):3347-3362. Eun Seong Hwang, Seon Beom Song
(72) A Rise in ATP, ROS, and Mitochondrial Content upon Glucose Withdrawal Correlates with a Dysregulated Mitochondria Turnover Mediated by the Activation of the Protein Deacetylase SIRT1. Cells. 2018. 27;8(1). pii: E11. Seon Beom Song and Eun Seong Hwang
(73) Enhancement of Replication and Differentiation Potential of Human Bone Marrow Stem Cells by Nicotinamide Treatment. Int J Stem Cells. 2018. 30;11(1):13-25. Jeong Su Ok, Seon Beom Song, Eun Seong Hwang
(74) Diverse therapeutic efficacies and more diverse mechanisms of nicotinamide. Metabolomics 2019. 15:137. SB Song, JS Park, GJ Chung, IH Lee, ES Hwang
(75) High Levels of ROS Impair Lysosomal Acidity and Autophagy Flux in Glucose-Deprived Fibroblasts by Activating ATM and Erk Pathways. Biomolecules 2020, 10, 761. SB Song and ES Hwang
(76) Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment. Biomolecules 2020, 10, 687. ES Hwang and SB Song.
Patent
(1) Pharmaceutical composition for enhancing immune response comprising nicotinamide as an actie ingredient. 2012,07.19 (Patent-2012-0078609) Eun Seong Hwang, Jeong Soo Ok, So Young Jang, Ho Jin Choi
(2) Pharmaceutical composition for preventing or treating chondrogenic disease comprising nicotinamides. 2017. 8. 18 (Patent number 10-1771151). Eun Seong Hwang, Jeong Soo Ok, Seon Beom Song
Books
(1) The Role of The Cellular Platelet-Derived Growth Factor Receptor in Cell Transformationby the Bovine Papillomavirus E5 Protien. Current Developments in Animal Virology. 1996. Science Publishers Inc., Lebanon, N.H., USA.(Eds. by S. Jameel and E.K. Wagner)
(2) Healthy Aging for Functional Longevity. Annals of the New York Academy of Science. Vol928. April. 2001. The New York Academy of Science (Editors: Sang Chul Park, Eun Seong Hwang, Hyun-Sook Kim, Woon-Yang Park)
(3) Manual for research and publication ethics in science and engineering.
Eun Seong Hwang, Eum Hee Cho, Young Mok Kim, Kibeom Park, Wha-Chul Son, Tae-Woong Yoon, Jeong Mook Lim. 2014. Korean Council of Science Editors (ISBN 978-89-97020-13-3 93190 )
(4) Pharmacological Nicotinamide: Mechanisms Centered Around SIRT1 Activity. In Phamacoepigenetics. Vol 10. 2019. Ed. by Ramon Cacabelos. Academic Press.
(1) Characteristics of two yeast strains and conditions for the protoplast formation and regeneration as a preliminary step in interspecific protoplast-fusion. 1984. Seoul Nat'l University, College of Agriculture Research 9: 1-16. K.H. Lee, K.H. Park, H.J. Lee, E.S. Hwang, H.C. Suh, B.H. Oh, and H.D. Jang
(2) Epstein-Barr Virus Nuclear Antigen Forms a Complex That Binds with High Concentration Dependence to a Single DNA-binding Site. 1987. J. Virology 61: 465-471. Gregory Milman and Eun Seong Hwang.
(3) Interaction of Integration Host Factor from Escherichia coli with the Integration Region of the Haemophilus influenzae Bacteriophage HP1. 1990. J. Bacteriology 172: 4852-4860. Eun Seong Hwang and John J. Scocca.
(4) Targeted Cleavage of Messenger RNA by Human RNaseP. 1992. Proceedings of the National Academy of Science, U.S.A. 89: 8001-8005. Yan Yuan, Eun Seong Hwang, and Sidney Altman.
(5) A method of cloning multiple direct repeats of DNA segment. 1993. Biotechniques 14: 766-767. Eun Seong Hwang and John J. Scocca.
(6) Inhibition of Cervical Carcinoma Cell Line Proliferation by Introduction of a Bovine Papillomavirus Regulatory Gene. 1993. J. Virology 67: 3720-3729. Eun Seong Hwang, David J. Riese,II, Jeffrey Settleman, Laura Nilson, Julie Honig, Stuart Flynn, and Daniel DiMaio.
(7) The E5 transforming Proteins of The Papillomaviruses. 1994. Seminars in Virology 5: 369-379. Daniel DiMaio, Lisa Petti, and Eun Seong Hwang.
(8) The HPV16 E5 Protein: Expression, Detection, and Stable Complex Formation with Trans-membrane Proteins in Cos Cells. 1995. Virology 211: 227-233. Eun Seong Hwang, Timothy Nottoli, and Daniel DiMaio.
(9) Endogenous Gene Expression of p53 and Regulatory Subunits of Cyclic AMP-dependent Protein Kinase in Ovarian Cancer Cells. 1995. Korean J. Zool. 38: 204-211. Jin Seo, Woonmee Park, Jong Sik Kim, Eun Seong Hwang, Je-Ho Lee, and Seung Hwan Hong.
(10) Activation of Endogenous Growth Inhibitory Pathways in HeLa Cervical Carcinoma Cells by Expression of the Bovine Papillomavirus E2 Gene. 1996. Oncogene 12:795-803. Eun Seong Hwang, Lisa K. Naeger, and Daniel DiMaio.
(12) Seroreactivities to HPV-16 Virus Like Particles (VLPs) using ELISA in the Patients with Cervical Neoplasia. 1996. Korean J Gynecology 39: 176-185. Jong Sup Park, Eun Seong Hwang, Hee Kyoung Ahn, Chan Ju Kim, Keun Taik Chung, Hyun Su Kim, Sue Nie Park, Sung Eun Namkoong, Seung Jo Kim.
(13) Identification of a Variant Estrogen Receptor Lacking Exon4 and Its Coexpression with Wild-type Estrogen Receptor in Ovarian Carcinomas. 1996. Clinical Cancer Research 2:2029- 2035. Weonmee Park, Jung-Joo Choi, Eun Seong Hwang, Je-Ho Lee.
(14) Physical Status and Expression of HPV Genes in Cervical Cancers. 1997. Gynecologic Oncol. 65: 121-129. Jong Sup Park, Eun Seong Hwang, Sue Nie Park, Hee Kyoung Ahn, Hye Kyung Yang, Chan Ju Kim, Seung Jo Kim, Sung Eun Namkoong.
(15) TypeII Protein Kinase A Up-regulation is Sufficient to Induce Growth Inhibition in SK-N-SH Human Neuroblastoma Cells. 1997. Biochem. Biophy. Res. Com. 232: 469-473. Se Nyun Kim, Gap Ryol Lee, Eun Seong Hwang, Je-HoLee, Sang Dai Park, Yoon S. Cho-Chung, and Seung Hwan Hong.
(16) Limited cytotoxic effect of adenoviral-mediated p53 gene transfer in variable non-small cell lung cancer (NSCLC) cell lines. J Korean Cancer Assoc. 1997. 29(45):565-57. Kim J, Lee SH, Hwang ES, Kim JS, Kim K, Lee JH.
(17) The effects of the adenovirus-mediated wild-type p53 delivery in human ovarian cancer cell lines in vitro and in vivo. 1998. International J. of Gynecol Cancer 8:27-36. Eun Seong Hwang, Jhingook Kim, Jong Sik Kim, Chinghai Kao, Song-Chu Ko, Lelend Chung, and Je-Ho Lee.
(18) Immunresponse to p53 and HPV16 E6 proteins in patients with cervical vacncer. 1998. International J. of Gynecol Cancer 8:542-547. Jong Sup Park, Soo Jong Um, Eun Seong Hwang, Sue Nie Park, Hee Kyoung Ahn, Chan Ju Kim, Sung Eun Namkoong.
(19) Induction of senescence-like state in HeLa cells by the expression of bovine papillomavirus E2 gene. 1998. Korean J Gerontology 8:57-65. Eun Seong Hwang
(20) Intraperitoneal gene therapy with adenoviral-mediated p53 tumor suppressor gene for ovarian cancer model in nude mouse. 1999. Cancer gene therapy. 6:172-178. Jhingook Kim, Eun Seong Hwang, Jong Sik Kim, Eun Hoi Ryu, Sook Hyun Lee, Je-Ho Lee.
(21) The antibody response to HPV proteins and genomic state of HPVs in patients with cervical cancer. 1999. Intern. J. of Gynecol Cancer 9:1-11. CJ Kim, SJ Um, ES Hwang, SN Park, SJ Kim, SE Namkoong.
(22) Bovine papillomavirus E2 protein activates a complex growth-inhibitory program in p53-negative HT-3 cervical carcinoma cells that includes repression of cyclin A and cdc25A phosphatase genes and accumulation of hypophosphorylated retinoblastoma protein. 1999. Cell Growth and Differentiation 10:1-10. L Naeger, E Goodwin, ES Hwang, R DeFillipis, H Zhang, and D DiMaio.
(23) Mutational and functional analysis of HPV16 URR derived from Korean cervical neoplasia. 1999. Gynecol Oncology 74:23-29. JS Park, ES Hwang, CJ Lee, CJ Kim, JG Rha, ES Namkoong, SJ Um.
(24) Antiproliferative effects of retinoic acid/interferon in cervical carcinoma cell lines: cooperative growth suppression of IRF-1 and p53. 2000. International J Cancer. 85:416-423. SJ Um, EJ Kim, ES Hwang, SJ Kim, SE Namkoong, JS Park.
(25) Inactivation of Interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. 2000. J Biol Chem. 275:6764-6769. JS Park, EJ Kim, HJ Kwon, ES Hwang, SE Namkoong, SJ Um
(26) Cellular machineries that regulate p53 tumor suppressor activity. 1999. Biochemistry News 19: 194-201. Eun Seong Hwang
(27) Rapid Induction of senescence in human cervical carcinoma cells. 2000. Proceedings of the National Academy of Science, U.S.A. 97:10978-10983. EC Goodwin, E Yang, CJ Lee, HW Lee, D DiMaio, ES Hwang
(28) Endothelin-1 autocrine is suppressed in HeLa cells induced to a senescent state. 2000. Korean J. Gerontology 10:31-37. Chan-Jae Lee, Jae-Yong Lee, Young-Sook Song and Eun Seong Hwang
(29) Effect of BPV1 E2-mediated inhibition of E6/E7 expression in HPV16-positive cervical carcinoma cells. 2001. Gynecol Oncology 80:168-175. MS Moon, CJ Lee, SJ Um, JS Park, JM Yang, ES Hwang
(29) Endothelin-1 autocrine is suppressed in HeLa cells induced to a senescent state. 2000. Korean J. Gerontology 10:31-37. Chan-Jae Lee, Jae-Yong Lee, Young-Sook Song and Eun Seong Hwang
(31) Abrogation of IRF-1 response by high-risk HPV E7 protein in vivo. 2002. Cancer Letters. 179: 205-212. Soo-Jong Um, Jae-Woong Rhyu, Eun-Joo Kim, Kook-Che Jeon, Eun Seong Hwang, Jong-Sup Park.
(32) Induction of Senescence-like State and Suppression of Telomerase Activity Through Inhibition of HPV E6/E7 Gene Expression in Cells Immortalized by HPV16 DNA. 2002. Experimental Cell Research. 277:173-82. Chan Jae Lee, Eun Jung Suh, Hyun Tae Kang, Jun Sub Im, Soo Jong Um, Jong Sup Park, and Eun Seong Hwang.
(33) Ribozyme-mediated replacement of p53 RNA by targeted trans-splicing. 2002. Journal of Microbiology and Biotechnology 12: 844-848. Shin, K.-S., Bae, S.-J., Hwang, E.S., Jeong, S., and Lee, S.-W.
(34) Replicative senescence and senescence-like state induced in cancer-derived cells. 2002. Mech Ageing Dev. 123:1681-1694. ES Hwang.
(35) Induction of senescence phenotypes in cancer cells by an acute growth arrest followed by ROS stress. 2002. Korean J Gerontology. 12:31-39. Bo Yun Lee and Eun Seong Hwang.
(36) BRCA1 associates with human papillomavirus type18 E2 and stimulates E2-dependent transcription. 2003. Biochem Biophys Res Comm. 305:1008-1016. Jiyun Kim, Daeyoup Lee, Sun Gwan Hwang, Eun Seong Hwang, Joonho Choe.
(37) 2-Deoxyglucose, a low glucose mimetic, downregulates HPV E6/E7 genes through modulation of glycosylation level of transcription factos in cervical cancer cells. 2003. Korea J. Gerontology. 13: 39-45. Hyun Tae Kang and Eun Seong Hwang.
(38) Downregulation of Sp1 activity through modulation of O-glycosylation by treatment with a low glucose mimetic, 2-deoxyglucose. 2003. J Biol Chem. 278:51223-51231. Hyun Tae Kang, Jung Won Ju, Jin Won Cho, and Eun Seong Hwang
(39) Transition to an irreversible state of senescence in HeLa cells arrested by repression of HPV E6 and E7 genes. 2004. Mech Ageing Dev. 125: 31-40. Hyun Tae Kang, Chan Jae Lee, Eun Jeong Seo, Young Jae Bahn, Hyun Jung Kim, and Eun Seong Hwang
(40) Mechanism of aging and modulation of aging at cellular level. 2004. Journal of Korean Society of Endocrinology. 19: 90-93. Eun Seong Hwang.
(41) The role of HPV oncoproteins and cellular factors in maintenance of hTERT expression in cervical carcinoma cells. 2004. Gynecologic Oncology. 94:40-47. Eun Jeong Seo, Hyun Jung Kim, Chan Jae Lee, Hyun Tae Kang, Eun Seong Hwang.
(42) Dinstinct ROS and biochemical profiles in cells undergoing DNA damage-induced senescence and apoptosis. 2004. Mech Ageing Dev. 126: 580-590. Young Sook Song, Bo Yun Lee, and Eun Seong Hwang
(43) 2-Deoxyglucose: an anti-cancer and anti-viral therapeutic, but not any more a low-glucose mimetic. 2006. Life Sciences 78: 1392-1399. Hyun Tae Kang and Eun Seong Hwang
(44) Senescence-associated β-galactosidase is lysosomal β-galactosidase. 2006. Aging Cell 5: 187-195. Bo Yun Lee, Jung A. Han, Jun Sub Im, Amelia Morrone, Kimberly Johung, Edward C. Goodwin, Wim J Kleijer, Daniel DiMaio, Eun Seong Hwang
(45) DNA-damage is critical to induce cellular senescence but not apoptosis. 2006. Kor J Gerontology. 16: 171-177. Young Sook Song and Eun Seong Hwang
(46) Nicotinamide extends replicative lifespan of human cells. 2006. Aging Cell 5:423-436.
Hyun Tae Kang, Hyung Il Lee, Eun Seong Hwang
(47) Downregulation of transcription factor, Sp1, during cellular senescence. 2007. BBRC. 353: 86-91. Ji-Eun Oh, Jung-A Han, Eun Seong Hwang
(48) DNA-damage is critical to induce cellular senescence but not apoptosis. 2006. Kor J Gerontol 16:171-177. Young Sook Song, Eun Seong Hwang
(49) Heterogeneous upregulation of lysosomal genes in human fibroblasts and cancer cells undergoing senescence. 2007. Korean J. Genetics 29: 521-527. Ji Hoon Park, Hye Won Yi, Daniel DiMaio, Eun Seong Hwang
(50) p53-, SIRT1-, and PARP-1-independent downregulation of p21WAF1 expression in nicotinamide treated Cells.2008. BBRC. 368: 298-304. Hyung I Lee, So-Young Jang, Hyun T Kang, Eun Seong Hwang
(51) Transient downregulation of protein O-GlcNAcylation by high-dose nicotinamide treatment in human cells. 2008. April. Experimental Molecular Medicine. 40: 246-253. Hyung Il Lee, Hwa Jeong Cho, Jung A Han, So-Young Jang, Kyoung Min Wang, Hyun Tae Kang, and Eun Seong Hwang
(52) Comparsion of cellular senescence phenotype in human fibroblasts from new-born and aged donors. 2008. J. Life Science 18:1-6. Hae Won Yi, Eun Seong Hwang
(53) Japan–Korea Joint Seminar: Asian Aging Core for Longevity 2008 in Nagasaki – Toward the establishment of an Asian Aging Research and Education Center. Mech. Ageing Dev. 130: 198–201. Isao Shimokawa, Sang Chul Park, Nozomu Mori, Eun Seong Hwang
(54) Nicotinamide enhances mitochondria quality through autophagy activation in human cells. 2009. Aging Cell. 8: 426–438. Hyun Tae Kang and Eun Seong Hwang
(55) A comparative analysis of the cell biology of senescence and aging. 2009. Cellular and Molecular Life Sciences. 66: 2503-2525. Eun Seong Hwang, Hyun Tae Kang, Gyesoon Yoon
(56) Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: Implication in the retinoic acid-induced neuronal differentiation of P19 cells. 2010. Nucleic Acids Res. 38: 822-831.
Kang MR, Lee SW, Um E, Kang HT, Hwang ES, Kim EJ, Um SJ.
(57) Fluorescence-Based Detection and Quantification of Features of Cellular Senescence. In: Zbigniew Darzynkiewicz, Elena Holden, Alberto Orfao, William Telf and Donald Wlodkowicord, editors: Recent Advances in Cytometry, Part B, Vol 103, Oxford: Academic Press; 2011, p149-188. Eun Seong Hwang
(58) Status of mTOR activity may phenotypically differentiate senescence and quiescence.
MolCells. 2012 Jun;33(6):597-604. Sohee Cho, Eun Seong Hwang
(59) Nicotinamide-induced mitophagy: Event mediated by high NAD+/NADH ratio and SIRT1 protein activation. J Biol Chem. 2012. 287:19304-14. So-young Jang, Hyun Tae Kang, Eun Seong Hwang
(60) GSK3 inactivation is involved in mitochondrial complex IV defect in transforming growth factor (TGF) β1-induced senescence. Exp Cell Res. 2013. 318(15): 1808-19. Byun HO, Jung HJ, Seo YH, Lee YK, Hwang SC, Hwang ES, Yoon G.
(61) Senescence suppressors: their practical importance in replicative lifespan extension in stem cells. Cell. Mol. Life Sci. 2014.71:4207-4219. Eun Seong Hwang
(62) High-Dose Nicotinamide Suppresses ROS Generation and Augments Population Expansion during CD8+ T Cell Activation. Mol. Cells. 2015. 38(10): 918-924. Ho Jin Choi, So-Young Jang, and Eun Seong Hwang
(63) Nicotinamide Exerts Antioxidative Effects on Senescent Cells. Mol Cells. 2015. 31; 38(3): 229–235. Ju Yeon Kwak, Hyun Joo Ham, Cheol Min Kim, and Eun Seong Hwang
(64) Chemical and Physical Approaches to Extend the Replicative and Differentiation Potential of Stem Cells. Stem Cell Rev. 2016. 12(3):315-26. Eun Seong Hwang, Jeong Soo Ok, Seon Beom Song
(65) Increased citation of Korean scholarly journals during the years 2008 to 2013. Sci Ed. 2016. 3(1):13-18. Eun Seong Hwang
(66) Equality, equity, and reality of open access on scholarly information. Sci Ed. 2017. 4(2):58-69. Jeong-Wook Seo, Hosik Chung, Tae-Sul Seo, Youngim Jung, Eun Seong Hwang, Cheol-Heui Yun, Hyungsun Kim
(67) On difficulty in handling text recycling. Sci Ed. 2017. 4(2):86-88. Eun Seong Hwang
(68) Increased number of papers co-authored by professor and his students in humanities and social sciences journals published in Korea. Sci Ed. 2017. 4(1):12-17. Rae Seong Hong, Eun Seong Hwang
(69) Modulation of Mitochondrial Membrane Potential and ROS Generation by Nicotinamide in a Manner Independent of SIRT1 and Mitophagy. Mol. Cells. 2017. 40(7): 503-514. Seon Beom Song, So-Young Jang, Hyun Tae Kang, Bie Wei, Un-woo Jeoun, Gye Soon Yoon, and Eun Seong Hwang
(70) Cellular NAD+ Level: A Key Determinant of Mitochondrial Quality and Health. Annals of Geriatric Medicine and Research. 2017. 21(4):149-157. Eun Seong Hwang, Sung Yun Hwang
(71) Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells. Cell. Mol. Life Sci. 2017. 74(18):3347-3362. Eun Seong Hwang, Seon Beom Song
(72) A Rise in ATP, ROS, and Mitochondrial Content upon Glucose Withdrawal Correlates with a Dysregulated Mitochondria Turnover Mediated by the Activation of the Protein Deacetylase SIRT1. Cells. 2018. 27;8(1). pii: E11. Seon Beom Song and Eun Seong Hwang
(73) Enhancement of Replication and Differentiation Potential of Human Bone Marrow Stem Cells by Nicotinamide Treatment. Int J Stem Cells. 2018. 30;11(1):13-25. Jeong Su Ok, Seon Beom Song, Eun Seong Hwang
(74) Diverse therapeutic efficacies and more diverse mechanisms of nicotinamide. Metabolomics 2019. 15:137. SB Song, JS Park, GJ Chung, IH Lee, ES Hwang
(75) High Levels of ROS Impair Lysosomal Acidity and Autophagy Flux in Glucose-Deprived Fibroblasts by Activating ATM and Erk Pathways. Biomolecules 2020, 10, 761. SB Song and ES Hwang
(76) Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment. Biomolecules 2020, 10, 687. ES Hwang and SB Song.
Patent
(1) Pharmaceutical composition for enhancing immune response comprising nicotinamide as an actie ingredient. 2012,07.19 (Patent-2012-0078609) Eun Seong Hwang, Jeong Soo Ok, So Young Jang, Ho Jin Choi
(2) Pharmaceutical composition for preventing or treating chondrogenic disease comprising nicotinamides. 2017. 8. 18 (Patent number 10-1771151). Eun Seong Hwang, Jeong Soo Ok, Seon Beom Song
Books
(1) The Role of The Cellular Platelet-Derived Growth Factor Receptor in Cell Transformationby the Bovine Papillomavirus E5 Protien. Current Developments in Animal Virology. 1996. Science Publishers Inc., Lebanon, N.H., USA.(Eds. by S. Jameel and E.K. Wagner)
(2) Healthy Aging for Functional Longevity. Annals of the New York Academy of Science. Vol928. April. 2001. The New York Academy of Science (Editors: Sang Chul Park, Eun Seong Hwang, Hyun-Sook Kim, Woon-Yang Park)
(3) Manual for research and publication ethics in science and engineering.
Eun Seong Hwang, Eum Hee Cho, Young Mok Kim, Kibeom Park, Wha-Chul Son, Tae-Woong Yoon, Jeong Mook Lim. 2014. Korean Council of Science Editors (ISBN 978-89-97020-13-3 93190 )
(4) Pharmacological Nicotinamide: Mechanisms Centered Around SIRT1 Activity. In Phamacoepigenetics. Vol 10. 2019. Ed. by Ramon Cacabelos. Academic Press.
