UOS-KU Team Developed a Real-Time Monitoring Model for Toxic Substances in Lung Diseases, Published in a Cover Paper of International Academic Journal
- Published in a Cover Paper of ‘Advanced Science’, international academic journal in the field of Materials Science(Aug 15th)
- Real-Time monitoring of Cellular Response Available in the similar condition of human lung with the developed Scaffolds
The joint research team(Professor Inhee Choi, department of Life Science, University of Seoul & Professor Jung Tae Park, department of Chemical Engineering, Konkuk University) developed “Alveoli-Like Multifunctional Scaffolds for Optical and Electrochemical In Situ Monitoring of Cellular Responses from Type II Pneumocytes”, which could not only observe cellular responses to various toxic substances that could be exposed to the lungs in real life situation, but also could be used for diagnosis, treatment, and drug developme nt of lung diseases.
▲ University of Seoul and Konkuk University Joint research team : (from the left) Prof. Inhee Choi(co-corresponding author), Prof. Jung Tae Park(co-corresponding author), Seonghyeon Eom(co-first author, Master’s course), So Yeon Lee(co-first author, Master’s course)
This research had been conducted by support of each groups’ mid-level research projects. The result were published as a cover paper in the latest issue(Aug 15th) of ‘Advanced Science’(IF: 15.1), an authoritative international academic journal in the field of materials science.
▲ Alveoli-Like Multifunctional Scaffolds and concept map of detection methods
Professor Inhee Choi(Co-corresponding author, department of Life Science, University of Seoul) lead the research team, which is composed of Seonghyeon Eom(co-first author, Master’s course, University of Seoul), professor Jung Tae Park(Co-corresponding author, department of Chemical Engineering, Konkuk University), and So Yeon Lee(co-first author, Master’s course, Konkuk University). The team conducted the research of developing cell culture scaffolds for fundamental understanding and treatment method improvement of lung diseases.
The research team introduced optically active gold nanoparticles and electroactive metal–organic framework crystals(MOF) to porous foam with dimensions like the alveoli structure, and showed that we could make optical and electrochemical monitoring of cellular responses in real time when the condition of the 3D cell cultures resembles the environment of vivo systems.
▲ Cover of ‘Advanced Science’ journal
The scaffolds were developed to monitor cellular reactants, such as various biomarkers and active oxygen, through label-free spectroscopy signals without complex pre-processing, due to excellent optical properties and effective signal amplification of gold nanoparticles. Further, it is designed to monitor the oxidative stress of a cell immediately by using excellent electrochemical activation of MOF and measuring the electric signal changes as a result of redox reaction.